Sensitivity analyses
One-way and tornado diagram showed that the probability of
hospitalization has the highest impact on the outcome, but MS was the
dominant strategy in all range of probabilities analyzed. The results of
PSA are graphically represented in the cost-effectiveness plane,figure 2 . 70.87% of simulations were graphed in quadrant 2
(lower cost , high QALYs) , and 28.4% in quadrant 1 of this plane (high
cost, high QALYs) . The 95% CI for the cost per patient treated with SM
and with standard treatment were US$ 1042 to 1257, and US$ 1471 to
1725. The 95% CI for QALYs per patient was 0.59 to 0.62 , and 0.51 to
0.54 respectively. The Cost-effectiveness acceptability curve shows that
the probabilty that MS provides a more cost-effective use of resources
compared with standard therapy exceeds 99% for all willingness to pay
thresholds. The population expected value of perfect information (EVPIP)
for threshold of US$ 20 000 (threshold of 3 times the Colombian per
capita gross domestic product) was US$ 221517 which was 15 times less
than maximum EVPIP simulated by the model.