Study |
Population |
Main
findings |
Wang D, et al
Retrospective case series
China
|
138 hospitalized patients with COVID-19
|
A. 102 (73.9%) patients admitted to isolation wards, and 36 (26.1%)
admitted to ICU because of organ dysfunction.
B. Patients admitted to ICU were significantly older, median (IQR) age
66 (57-78) years vs 51 (37-62) years, P < 0.001), more likely
to have hypertension (58.3%) vs (21.6%), diabetes (22.2%) vs (5.9%),
CVD (25.0%) vs (10.8%) and cerebrovascular disease (16.7%) vs (1.0%)
compared to those who were not in ICU.
|
Chinese CDC,
Cross sectional analysis.
|
44,672 confirmed cases of COVID-19
|
A. Total 1,023 deaths occurred, crude fatality rate 2.3%.
B. Crude fatality rate of patients with no comorbidities 0.9%.
C. Fatality rate of patients with comorbidities 10.5% for CVD, 7.3%
for diabetes, 6.3% for chronic respiratory disease, 6.0% for
hypertension and 5.6% for cancer.
|
Zhou F, et al
Retrospective, multicentre,
China
|
191 patients hospitalised with COVID-19
|
A. 54 (28%) patients died in hospital.
B. In univariable analysis, odds of in-hospital death was higher in
patients with diabetes (OR 2.85, 95% CI 1.35 to 6.05) or coronary heart
disease (21.1, 4.64 to 98.76).
|
Roncon L, et al,
Data base analysis
Italy
|
1,382 patients hospitalised for COVID-19
|
A. Mean age 51.5 years, 58% men.
B. Patients with diabetes had a significantly higher risk for ICU
admission (OR 2.79, 95% CI 1.85 to 4.22, p < 0.0001) and
mortality (3.21, 1.82 to 5.64, p < 0.000).
|
Chen Y, et al.
Data base analysis
China
|
1,936 patients with COVID-19.
|
There were significant correlations between COVID-19 severity and
hypertension (OR 2.3, 95% CI 1.76 to 3.00, P<0.01), diabetes
(67, 1.91 to 3.74, P<0.01), coronary heart disease (2.85, 1.68
to 4.84, P<0.01).
|
Bo L, et al.
Data analysis
China
|
1,527 patients with COVID-19.
|
A. Proportions of hypertension, CCVD and diabetes were 17.1%, 16.4%
and 9.7%, respectively.
B. Incidences of hypertension, CCVD and diabetes were twofold, threefold
and twofold, respectively higher in ICU/severe cases compared to
non-ICU/severe counterparts.
C. Diabetes accounted for 11.7% of ICU/severe cases and 4.0% of
non-ICU/severe cases, RR 2.21, 95% CI 0.88 to 5.57,
P = 0.09>
|
Guan WJ, et al.
Retrospective
China
|
1,099 patients with COVID-19.
|
A. 81 (7.4%) of patients had diabetes.
B. Primary composite end point of admission to ICU, mechanical
ventilation or death occurred in 26.9% of patients with diabetes, only
second to hypertension (35.8%).
|
WU C, et al
Retrospective
China
|
201 patients with COVID-19.
|
A. 41.8% of patients developed ARDS.
B. Patients with compared to those without ARDS, had comorbidities such
as hypertension (27.4% vs 13.7%, difference 13.7%, 95% CI 1.3% to
26.1%) and diabetes (19.0% vs 5.1%, difference 13.9%, 95% CI 3.6%
to 24.2%).
|
Yang X, et al
Retrospective
China
|
52 critically ill patients with COVID-19.
|
A. 98% had chronic illness.
B. 61.5% died at 28 days.
C. Top comorbidities among non-survivors were diabetes (22%) and CVD
(22%).
|
Yuan M, et al
Retrospective
China
|
27 patients with COVID-19.
|
A. 10 patients died in hospital.
B. Patients who died were significantly older (median age 68 vs 55
years, p=0.003), had more comorbidities (80% vs 29%, p=0.02), diabetes
(60% vs 0%, p=0.001), hypertension (50% vs 0%,p=0.003) and CVD (30%
vs 0%, p=0.04).
|
Yang J, et al
Data analysis
China
|
1,576 patients with COVID-19.
|
Significant comorbidity differences between severe and non-severe group
were hypertension (OR 2.36, 95% CI 1.46 to 3.83), respiratory disease
(2.46, 1.76 to 3.44), CVD (3.42, 1.88 to 6.22) but diabetes was not
statistically significant (2.07, 0.89 to 4.82).
|
Shabto JM, et al
Retrospective, US
|
65 DM and COVID-19 patients
|
Telemedicine outpatient follow up showed the rate of hospitalisation for
patients with diabetes double (10.2%) that of other patients
(5.1%).
|
Zhang Y, et al
Retrospective
China
|
258 (63 with diabetes) hospitalised COVID-19 patients.
|
A. Median age 64 years (range 23-91).
B. Patients with diabetes were more likely to develop severe disease,
more complications, mechanical ventilation and death (11.1% vs. 4.1%).
C. Diabetes (aHR 3.64, 95% CI 1.09 to 12.21) and fasting blood glucose
(1.19, 1.08 to 1.31) were associated with the fatality.
|
Williamson E, et al
Data base analysis, UK
|
17,425,445 NHS registered adults.
|
A.5683 died of COVID-19.
B. Uncontrolled diabetes (HbA1c>+7.5%) increased risk of
death (HR 2.36, 95% CI 2.18 to 2.56).
|