3.6 Viral excretion is decreased in pCIgD-Man-L group
Bovines were challenged at 90 dpv via aerosol with BoHV-1 strain Los
Angeles. In order to measure the viral excretion after virus challenge
trial, nasal secretions were obtained by inserting tampons into each
nostril and collected the secretion.
In this assay, pCIgD and pCIgD-Man-L treatment were capable to reduce
viral excretion compared to pCIneo treated group but the bovines that
received pCIgD-Man-L formulation presented a markedly reduction of
excretion at 5 dpc compared with pCIneo group (p<0.01). This
phenomenon was not observed in the pCIgD group (Fig 6 ). In
addition, these results were analyzed as area under curve (AUC) of the
viral titer. In this way, AUC of the viral titer in animal treated with
pCIgD-Man-L was the lowest with respect to the other groups.