3.6 Viral excretion is decreased in pCIgD-Man-L group
Bovines were challenged at 90 dpv via aerosol with BoHV-1 strain Los Angeles. In order to measure the viral excretion after virus challenge trial, nasal secretions were obtained by inserting tampons into each nostril and collected the secretion.
In this assay, pCIgD and pCIgD-Man-L treatment were capable to reduce viral excretion compared to pCIneo treated group but the bovines that received pCIgD-Man-L formulation presented a markedly reduction of excretion at 5 dpc compared with pCIneo group (p<0.01). This phenomenon was not observed in the pCIgD group (Fig 6 ). In addition, these results were analyzed as area under curve (AUC) of the viral titer. In this way, AUC of the viral titer in animal treated with pCIgD-Man-L was the lowest with respect to the other groups.