2.1 Chemical Synthesis
The most prominent route for traditional pyrazine synthesis is the
reaction of 1,2-diketones in the presence of ammonia to form diamines or
aminoketones [22]. The list of examples is long, nevertheless an
easy high yielding representative example is the reaction of diketones
with diamines in methanol at room temperature under dry conditions in
the presence of tert -BuOK in up to 5 hours, that yields above 70
% of alkylated pyrazines [23].