Literature review and evidence summary
A background literature review and synthesis of the evidence was undertaken by a core group of the panel, and key evidence summarised (see Appendix 1). A recently updated version of the Cochrane review, ‘Biologics for chronic rhinosinusitis’ was circulated in full, along with another recent systematic review of use in CRSwNP(7) and two previously published guidelines on indications for use of biologics, from EPOS(8) and EUFOREA(9). Key outcomes from relevant trials were summarised and circulated in data tables (Appendix 2).