Introduction
Lymphadenopathy (LAD) can present features including connective tissue diseases, malignancy, and infections. A histopathological evaluation for a definitive diagnosis should be conducted in specific clinical scenarios. Systemic lupus erythematosus (SLE) is an autoimmune and chronic disease involving multi-organs (1, 2).
In approximately 60% of SLE cases, generalized or localized LAD are prevalent findings. Numerous case reports have shown that the SLE’s initial clinical manifestation might be generalized LAD and is considered as an SLE non-specific feature (3, 4).
Castleman disease (CD) is a rare lymphoproliferative disorder characterized by heterogeneous manifestations from diffuse recurrent episodes of lymphadenopathy with severe systemic symptoms to asymptomatic LAD. There are some CD case reports accompanying SLE.(5-7). Hence, this article illustrates a rare CD case presenting LAD in a patient with SLE.