Statistical Methods
Demographic information and absolute imaging diameters at the level of the sinuses of Valsalva (SoV) and ascending aorta (AAo) were obtained. All echocardiogram Z-scores were either obtained directly from the reports or calculated [12, 13]. For advanced imaging where bi-orthogonal measurements were obtained, the largest diameter was used in the analysis. Data was also analyzed by dividing the patients into two groups: birth -16 years of age and 17-30 years of age (Tables 5-6). Genetics diagnoses were obtained from laboratory reports or documentation from the cardiac geneticist or primary cardiologist (Table 2). Echocardiographic aortic dimensions were analyzed using median and interquartile ranges. Pearson correlation was used to compare echocardiography and advanced imaging aortic dimensions and p-values calculated using R (R Project for Statistical Computing, version 3.5.1). Bland-Altman (B-A) analysis plots [14] were created to compare differences of measurements between echo and advanced imaging at the SoV and AAo using R.