Goal of the study
Primary endpoints were operative mortality, NE and need of renal
replacement therapy (RRT). Secondary endpoints were time to extubation,
need of tracheostomy and intensive care unit (ICU) length of stay (LOS).
Operative mortality included 30 day or in-hospital mortality. NEs
included stroke (defined as a cerebrovascular accident confirmed by
radiologic imaging, computed tomography or magnetic resonance imaging)
and seizures, localized or generalized, with or without positive
radiologic imaging. According the clinical outcome, NEs were classified
as temporary (TNEs) or permanent neurologic deficits (PNDs). The effect
of temperature on lower body protection was evaluated by acute kidney
injury (AKI) necessitating RRT. Changes in kidney function were also
analysed according the KIDGO criteria3. Primary
endpoints were analysed separately, grouped as death and PND or as
composite endpoint (death, PND and need of RRT).
Results were reported for the whole statistics and were compared as well
between the two groups.