Legend. DHCA, deep hypothermic circulatory arrest; DR, delayed rewarming; MHCA, moderately hypothermic circulatory arrest; ACP, antegrade cerebral perfusion; NE, neurologic event; ND, neurological deficit; RRT, renal replacement therapy; ICU, intensive care unit; LOS, length of stay; KDIGO, Kidney Disease: Improving Global Outcome.
Table 3 – Endpoints in the two groups: weighed logistic regression.
Endpoints DHCA+DR MHCA+ACP p WLR
Death 1(1.7) 13(8.6) 0.072 5.46(0.7-42.7)
Any NE 1(1.7) 16(10.6) 0.034 4.65(0.89-53.0)
PND 1(1.7) 9(5.9) 0.089 4.22(0.44-28.9)
Death and PND 2(3.4) 19(12.5) 0.046 8.98(0.90-36.2)
Need of RRT 0 23(15.2) 0.001 7.39(1.37-79.1)
Compositeª 2(3.4) 33(24.9) 0.001 8.97(1.95-35.3)
Legend. DHCA, deep hypothermic circulatory arrest; DR, delayed rewarming; MHCA, moderately hypothermic circulatory arrest; ACP, antegrade cerebral perfusion; WLR, weighed logistic regression; PND, permanent neurologic deficit; RRT, renal replacement therapy.
ªDeath, PND and RRT
Table 1 supplement – Secondary endpoints in patients without composite primary endpoint.
DHCA+DR MHCA+ACP p
n=57 n=118
Time to extubation (min) 590(356-878) 720(431-1255) 0.007
Tracheostomy 0 4(3.4) 0.105
ICU LOS (days) 2(1-3) 3(2-6) <0.001
Legend. DHCA, deep hypothermic circulatory arrest; DR, delayed rewarming; MHCA, moderately hypothermic circulatory arrest; ACP, antegrade cerebral perfusion; ICU, intensive care unit; LOS, length of stay.