Remdesivir
Remdesivir (GS-5734) is an adenine derivative phosphoramidate prodrug with a chemical structure similar to that of tenofovir alafenamide, an approved inhibitor of HIV reverse transcriptase. Remdesivir has broad- effects in cell cultures and animal models against RNA viruses, such as - MERS and SARS, and has been checked for Ebola in a clinical trial. A recent research confirmed that Remdesivir inhibited 2019-nCoV, when tested in concentrations of EC50 = 0.77 μM in Vero E6 cells [10] One US patient with 2019-nCoV was reported to get recovered after receiving intravenous remdesivir in January 6, as trials in patients with 2019-nCoV (NCT04252664 and NCT04257656) were initiated in early February to evaluate intravenous Remdesivir (200 mg on day 1 and 100 mg once daily for 9 days), with estimated completion dates in April 2020 [11]. Notably, Remdesivir (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87) at low-micromolar concentration, effectively blocked virus infection and showed high SI [12]. Preliminary data suggested that Remdesivir also effectively blocked virus infection in a human cell line (Huh-7 cells of human liver cancer), which is immune to 2019-nCoV and currently, it is in the Phase III of clinical trial established by China.