Ibuprofen
Ibuprofen is a propionic acid-derived non-steroidal anti-inflammatory
drug (NSAID), and is known to be the first propionic. Theformula of
Ibuprofen is 2-(4-isobutylphenyl) propionic acid, originally discovered
in 1960, while looking for a safer alternative of aspirin. Ibuprofen was
eventually patented in 1961, and this drug was first introduced in the
UK in 1969 and in the USA in 1974 against rheumatoid arthritis. It was
the first NSAID available over the counter [36]. The ibuprofen is
given as a racemic mixture on the available drugs. The R-enantiomer,
undergoes comprehensive interconversion to the S-enantiomer in vivo
through the action of racemase alpha-methylacyl-CoA, when its
administered. It is commonly proposed; in particular, that the
S-enantiomer is capable of generating greater pharmacological activity
than the R-enantiomer [35], and its ability against 2019-nCoV is
unclear and could be screened for further analysis.