What’s known
There is extensive knowledge of the risk of ADE in prior viral epidemics of SARS, MERS and RSV, extensive knowledge about the molecular similarities between SARS, MERS and SARS-CoV-2, the causative agent of COVID-19, extensive knowledge about the pattern of COVID-19 disease in individuals and populations and extensive knowledge about the composition and design of SARS, MERS and COVID-19 vaccines.