Future directions
An updated review of described cases is necessary to add to the body of
evidence and improve the quality of data. In addition, further studies
on the pathophysiology and possible markers are needed to better
understand this disease.
There is also need for better reporting of available data, described
cases should be thorough and include exams, interventions and both fetal
and maternal outcomes. We highly recommend that in the suspicion of
mirror syndrome, attending physicians request PlGF and sFlt-1 exams to
help validate these tools as a diagnostic aid since currently there
isn’t enough evidence to qualify these markers and the diagnosis of
Mirror syndrome remains a challenge.