Secondary outcomes and safety assessment
Secondary outcomes included the proportion of individuals with a negative RT-PCR test for respiratory SARS-CoV-2 on the 15th day after the onset of symptoms or on the 15th day after the initial positive RT-PCR test, incidence of turning critically ill, needs for mechanical ventilation and oxygen therapy. In addition, a safety evaluation of the nirmatrelvir-ritonavir was conducted by examining the medical records of patients to identify potential adverse effects (AEs) such as diarrhea and stomach discomfort. Monitoring for AEs began at the start of treatment and continued until the patient was released from the hospital.