Secondary outcomes and safety assessment
Secondary outcomes included the proportion of individuals with a
negative RT-PCR test for respiratory SARS-CoV-2 on the
15th day after the onset of symptoms or on the
15th day after the initial positive RT-PCR test,
incidence of turning critically ill, needs for mechanical ventilation
and oxygen therapy. In addition, a safety evaluation of the
nirmatrelvir-ritonavir was conducted by examining the medical records of
patients to identify potential
adverse effects
(AEs) such as diarrhea and stomach
discomfort. Monitoring for AEs began at the start of treatment and
continued until the patient was released from the hospital.