Active agents on RAS and SARS-CoV-2
As previously reported SARS-CoV-2 uses the angiotensin 2 conversion enzyme (ACE2) as a receptor binding domain. Based on this, and considering the crucial role of the RAS system and the enzyme ACE-2 in the acute respiratory syndrome caused by SARS-CoV-2 and the correlation with the inflammatory status of lung tissues, it could be considered important to assume that the therapeutic agents acting on RAS, could modulate the viral infection with SARS-CoV-2, with an effect of improvement or worsening, and that managing these drugs in the most timely manner could be of great benefit. The active agents on RAS available may interfere with various stages of the system, an inhibitory action of the enzyme ACE (ACE-i), blocking Angiotensin II (ARB) receptors, inhibitors direct renin. ACE-i and ARB are the drugs of choice for the treatment of hypertension, heart failure and ischemic heart disease.(figure-1)