Optimum dosage
Evidence from the treatment of past epidemics with PT, and the results currently available indicate that the correct dose of convalescent plasma to be administered may be variable depending on a different indication, whether it is in prophylaxis or treatment. The reported studies have used approximately (200 mL) units of plasma (19), however, in the various clinical studies currently underway, therapeutic regimens for post-exposure prophylaxis and therapeutic regimens for the treatment of infection have been proposed. The duration of effectiveness of PT is not known, but it is hypothesized that to last from weeks to a few months (20) . For a patient of about 80 Kg, the standard dose to be used for the treatment should be in dependence of the various supporting studies, about 250 ml of plasma, in the pediatric population (experiments are being planned), there will be a need for doses according to body weight. However, there are currently levels of uncertainty about the optimal dose.