Cumulative pregnancy and LBRs
Cumulative pregnancy and live birth rates are listed in Table II. The CLBR after one complete IVF cycle including fresh and subsequent frozen embryo cycles within 18 months follow up were significantly lower in the PPOS group compared that in the long agonist group 206/509 (40.5%) and 307/486 (63.2%), respectively (odds ratio (OR): 0.641; 95% CI: 0.565-0.726). The average time from ovarian stimulation to pregnancy and live birth was significantly shorter in the long agonist group compared to the PPOS group (P < 0.001) (Table II). In Kaplan-Meier analysis, the cumulative incidence of ongoing pregnancy leading to live birth was significantly higher in the long agonist compared in the PPOS group.( Log rank test, P < 0.001) (Fig. 2)
Cox proportional hazard model using the stepwise method by the women’s age, stimulation protocol (PPOS/agonist), body mass index, duration of infertility, total FSH dosage, number of retrieved oocytes, causes of infertility, starting dose of FSH, days of stimulation, oestradiol and LH level on HCG day, only stimulation protocol and starting dose of FSH was entered in this model and revealed stimulation protocol adopted was strongly associated with the cumulative live birth rate after adjusting other confounding factors.(OR =1.917 (1.152-3.190), P = 0.012) (Table V).