Cumulative pregnancy and LBRs
Cumulative pregnancy and live birth rates are listed in Table II. The
CLBR after one complete IVF cycle including fresh and subsequent frozen
embryo cycles within 18 months follow up were significantly lower in the
PPOS group compared that in the long agonist group 206/509 (40.5%) and
307/486 (63.2%), respectively (odds ratio (OR): 0.641; 95% CI:
0.565-0.726). The average time from ovarian stimulation to pregnancy and
live birth was significantly shorter in the long agonist group compared
to the PPOS group (P < 0.001) (Table II). In Kaplan-Meier
analysis, the cumulative incidence of ongoing pregnancy leading to live
birth was significantly higher in the long agonist compared in the PPOS
group.( Log rank test, P < 0.001) (Fig. 2)
Cox proportional hazard model using the stepwise method by
the women’s age, stimulation
protocol (PPOS/agonist), body mass index, duration of infertility, total
FSH dosage, number of retrieved oocytes, causes of infertility, starting
dose of FSH, days of stimulation, oestradiol and LH level on HCG day,
only stimulation protocol and starting dose of FSH was entered in this
model and revealed stimulation protocol adopted was strongly associated
with the cumulative live birth rate after adjusting other confounding
factors.(OR =1.917 (1.152-3.190), P = 0.012) (Table V).