AUTHOR CONTRIBUTIONS
YZ, TH, and YW conceived this study. JY, NH, ZY, JY, ZS, ZX and ZW recruited participants and collected samples. XL and YY performed the metabolomics analysis and analyzed data under the guidance of TH. JY, XL, RS, JMC, YW, TH and YZ reviewed and edited the manuscript. All authors provided critical intellectual content and approved the final manuscript.