Elecsys Immunoassay sFlt-1/PlGF ratio (Roche Diagnostics)
The Elecsys sFlt-1/PlGF ratio is derived by combining the results from two CE-approved sandwich electrochemiluminescence immunoassays. The analysis turnaround time is 18 minutes. The test requires a large-scale laboratory analyser and is not a point-of-care test. The Elecsys sFlt-1 assay has a lower limit of detection of 10pg/ml and a range of 10 – 85,000pg/ml. The Elecsys PlGF assay has a lower limit of detection of 3pg/ml and a range of 3 to 10,000pg/ml. The National Institute for Health and Care Excellence recommends use as a rule-out test for suspected pre-eclampsia between 20 and 34+6 weeks’ gestation, at a threshold of ≤ 38.9