Details of Ethics Approval
The study was approved by the Institutional Review Board of the First Affiliated Hospital of Zhengzhou University (2018-KY-41; date of approval 14 August 2018). All patients provided written informed consent.

Funding: sponsored by Program for Science and Technology Innovation Talents in Henan Province (2018JR0004) and ZhongYuan thousand talents program-the Zhongyuan eminent doctor in Henan province (ZYQR201810107) and National Natural Science Foundation of China (31670844).