Study design and setting
The study was a single centre, parallel group, prospective randomised
controlled trial conducted at a large University hospital in London UK
from August 2018 to October 2018 (Whipps Cross University Hospital). The
study was approved by the National Research Ethics Committee, Health
Research Authority and registered as a clinical trial.
(ClinicalTrials.gov Identifier: NCT03699280). This research did not
receive any external funding.