Multivariate logistic regression analysis for adverse obstetric outcomes in pregnancies with myoma or following myomectomy
Both groups of women with a history of diagnosed myoma(s) and women with a history of myomectomy had significantly higher risks of cesarean section (aOR 1.13, 95% CI 1.1-1.16, p = 0.042; and aOR 7.46, 95% CI 6.97-7.98, p < 0.001, respectively) and placenta previa (aOR 1.41, 95% CI 1.29-1.54, p = 0.042; and aOR 1.58, 95% CI 1.35-1.83, p < 0.001, respectively), compared to women without a diagnosed myoma (Table 3). However, women with a history of myomectomy had a significantly higher risk of uterine rupture (aOR 12.78, 95% CI 6.5-25.13, p < 0.001). We evaluated incidences of uterine rupture in women with myomectomy, according to the time interval after myomectomy (Figure 2). The incidence of uterine rupture was significantly higher at delivery within one year after myomectomy (0.71%) compared to any longer delivery interval after myomectomy.
Finally, we compared obstetric outcomes in dataset 2 (Table 4). The group of women with a history of myomectomy had significantly higher risks of preterm birth (aOR 1.64, 95% CI 1.47-1.84, p< 0.001) and LBW (aOR 1.53, 95% CI 1.39-1.68, p< 0.001) than did women without a diagnosed myoma. However, women with diagnosed myoma(s) and women with a history of myomectomy had a significantly lower risk of LGA (aOR 0.97, 95% CI 0.90-1.04, p= 0.002; and aOR 0.68, 95% CI 0.597-0.79, p < 0.001, respectively).