Multivariate logistic regression analysis for adverse
obstetric outcomes in pregnancies with myoma or following myomectomy
Both groups of women with a history of diagnosed myoma(s) and women with
a history of myomectomy had significantly higher risks of cesarean
section (aOR 1.13, 95% CI 1.1-1.16, p = 0.042; and aOR 7.46,
95% CI 6.97-7.98, p < 0.001, respectively) and
placenta previa (aOR 1.41, 95% CI 1.29-1.54, p = 0.042; and aOR
1.58, 95% CI 1.35-1.83, p < 0.001, respectively),
compared to women without a diagnosed myoma (Table 3). However, women
with a history of myomectomy had a significantly higher risk of uterine
rupture (aOR 12.78, 95% CI 6.5-25.13, p < 0.001). We
evaluated incidences of uterine rupture in women with myomectomy,
according to the time interval after myomectomy (Figure 2). The
incidence of uterine rupture was significantly higher at delivery within
one year after myomectomy (0.71%) compared to any longer delivery
interval after myomectomy.
Finally, we compared obstetric outcomes in dataset 2 (Table 4). The
group of women with a history of myomectomy had significantly higher
risks of preterm birth (aOR 1.64, 95% CI 1.47-1.84, p< 0.001) and LBW (aOR 1.53, 95% CI 1.39-1.68, p< 0.001) than did women without a diagnosed myoma. However,
women with diagnosed myoma(s) and women with a history of myomectomy had
a significantly lower risk of LGA (aOR 0.97, 95% CI 0.90-1.04, p= 0.002; and aOR 0.68, 95% CI 0.597-0.79, p < 0.001,
respectively).