Figure 2. Bias plot of an equimolar comparison of ligand-induced activities in two pathways.
The plot is adapted from (White et al., 2014) in which Salvinorin A was chosen as the reference ligand because it has a slope close to 1. It also has very similar pEC50 values (5.2 and 5.8) for both the G protein and arrestin pathways and displays full efficacy at both pathways.