Data and statistical analysis
The data and statistical analysis comply with the recommendations on experimental design and analysis in pharmacology (Curtis et al. , 2018). Since in microdialysis studies, particularly when amino acid are measured, baseline values can differ greatly from animal to animal, to minimize experimental variability data were normalized as percent of baseline values, as in our previous publications. Statistical analysis was performed (Graphpad Prism 6.0) on area-under-the curve values (AUC; calculated in the 100-220 min range) followed by the Newman-Keuls test for multiple comparisons. AIMs were statistically analysed using the Mann-Whitney U-test or the Kruskal-Wallis test followed by the Dunn test for multiple comparisons when more than two groups were compared. Alpha was set at 0.05.