Discussion
The role of striatal and nigral M1 and M4 muscarinic receptors in LID
was investigated using a dual probe microdialysis approach
(Mela et al. , 2012) by which M1
and M4 receptor preferential antagonists and a M4 receptor selective PAM
were delivered through the microdialysis probe into the dorsolateral
striatum or SNr, simultaneously with systemic L-DOPA administration.