Many chronic inflammatory diseases share features compatible with the PHM hypothesis
Features of diverse chronic inflammatory diseases suggest compatibility with the PHM hypothesis[1]. Briefly, allergy/hypersensitivity to foods and inhalants is increasingly being found in autoimmune and other inflammatory diseases. Stress has been found to be associated with the initiation and exacerbation of many inflammatory diseases. Markers of chronic stress, such as elevated heart rate and low heart rate variability, have been associated with numerous diseases and all-cause mortality. Opportunistic pathogen presence and/or dysbiosis has been documented in many diseases. Autoantibodies are increasingly being found in diverse inflammation-related and allergic diseases. More traditional diets that reduce consumption of ultra-processed foods/beverages (e.g., Mediterranean diet) are showing benefit.