Complete 15N-labeling of DNA causing an increase in CsCl buoyant density in the range of 0.013 to 0.017 g ml–1
(Buckley et al., 2007a, Cadisch et al., 2005, Cupples et al., 2007).
and have revealed that a difference of at least 30 atom% 15N is required to conclusively detect a difference in CsCl buoyant density between DNA molecules with different levels of isotope incorporation (Buckley et al., 2007a).
40% according to \cite{Cadisch_2005}
- Raman, Nano-SIMS, protein-SIP