Single-cell gene expression
Source of variation in scRNA-seq
Highly variable genes in
The problem: What is the function of the gene-expression noise in a homogeneous population of cells?
The result: Highly variable genes in homogeneous populations of cells are related to the specific function of the cell type
During multicellular organisms development, differentiation of cell types generates specific gene expression patterns for each cellular lineage; when gene expression profiles at the single-cell level are sequenced within the same tissue, these cell-type-specific genes are commonly identified as high variable genes. Research associated with the identification of highly variable genes
allowing to identify subpopulations of cells by dimensionality reduction methods.