The utility of identifying highly variable genes
Highly variable genes in a homogeneous population of cells
During multicellular organisms development, differentiation of cell types generates specific gene expression patterns for each cellular lineage; when gene expression profiles at the single-cell level are sequenced within the same tissue, these cell-type-specific genes are commonly identified as high variable genes. Research associated with the identification of highly variable genes
allowing to identify subpopulations of cells by dimensionality reduction methods.