We can’t exactly define the boundaries for a new building in Rome nor in Kathmandu, this because, as we could have already seen before, we do not know exactly the climate in a specific are nor the position of the building or the materials avaiable, but, starting from basic average information and data, we could give some indication. The big difference in the two climates is the average temperature in the heating period and the precipitation.
Having a look to the weather data, we can easily understand that the main problem in Rome will be during summer, but for what concerns the cooling, since the winter is not so rigid it would be enough just to pay attention to the insulation part of the wall stratigraphy, and for Kathmandu will be to minimize the moisture transfer and the energy need for cooling.