Figure 3: Protein predictors in relation to the clinical response to dupilumab. Quantification of selected protein candidates in serum by ELISA. A, D, G, I panels shows protein levels in AD patients (paired samples before and after therapy), psoriasis patients and healthy individuals. B, E, H, J panels show differences in AD patients (paired samples before and after therapy) in three groups of responders (low, high and super responders). Comparisons between unpaired groups were done by Mann-Whitney U test and paired groups by Wilcoxon test. C, F: Spearman’s rank correlation of the selected biomarkers to SCORAD, BSA, and itch on a VAS in AD patients (pre and post therapy).