Figure 5: Skin bacterial species ratio changes upon dupilumab therapy. A) Ratio of bacterial DNA of three bacterial species before and after initiating dupilumab therapy. B) S. aureus to C. acnes ratio in 4 grades of IGA score of AD patients. C)Ratio of S. aureus to C. acnes before therapy in 3 responder groups.D) Ratio of S. aureus, C. acnes and S. epidermidis in AD patients before and after therapy. E) Correlation of S. aureus to C. acnes bacterial DNA ratio with SCORAD and BSA clinical scores. The blue line represents a generalized additive model’s smoothness estimation.