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Influence of the mutation load on the genomic composition of hybrids between outcrossing and self-fertilizing species
  • Frédéric Fyon,
  • Waldir Berbel Filho
Frédéric Fyon
Royal Holloway University of London

Corresponding Author:[email protected]

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Waldir Berbel Filho
University of Oklahoma
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Hybridization is a natural process whereby two diverging evolutionary lineages reproduce and create offspring of mixed ancestry. Differences in mating systems (e.g., self-fertilization and outcrossing) are expected to affect the direction and extent of hybridization and introgression in hybrid zones. Among other factors, selfers and outcrossers are expected to differ in their mutation loads. This has been studied both theoretically and empirically; however, conflicting predictions have been made on the effects mutation loads of parental species with different mating systems can have on the genomic composition of hybrids. Here we develop a multi-locus, selective model to study how the different mutation load built up in selfers and outcrossers as a result of selective interference and homozygosity impact the long-term genetic composition of hybrid populations. Notably, our results emphasize that genes from the parental population with lesser mutation load get rapidly over-represented in hybrid genomes, regardless of the hybrids own mating system. When recombination tends to be more important than mutation, outcrossers’ genomes tend to be of higher quality and prevail. When recombination is small, however, selfers’ genomes may reach higher quality than outcrossers’ genomes and prevail. Taken together these results provide concrete insights into one of the multiple factors influencing hybrid genome composition and introgression patterns in hybrid zones with species containing species with different mating systems.
31 May 2023Submitted to Ecology and Evolution
01 Jun 2023Submission Checks Completed
01 Jun 2023Assigned to Editor
05 Jun 2023Reviewer(s) Assigned
22 Jun 2023Review(s) Completed, Editorial Evaluation Pending
29 Jun 2023Editorial Decision: Revise Minor
24 Jul 20231st Revision Received
25 Jul 2023Submission Checks Completed
25 Jul 2023Assigned to Editor
25 Jul 2023Review(s) Completed, Editorial Evaluation Pending
04 Sep 2023Editorial Decision: Accept