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Interferon-stimulated gene 15 (ISG15) deficiency in dendritic cells protects against contact hypersensitivity (CHS) inflammation in mouse.
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  • Francisco Sánchez-Madrid,
  • Irene Fernández-Delgado,
  • Raquel Castillo-González,
  • Raúl Izquierdo-Serrano,
  • Elena Moya-Ruiz,
  • Marta Ramírez-Huesca,
  • Olga Moreno-Gonzalo,
  • Ana Rodríguez-Galán,
  • Nieves Fernández-Gallego Anaya,
  • Alberto Fernández-Bernaldez,
  • Javier Sanchez-Perez,
  • Danay Cibrian,
  • Hortensia de la Fuente,
  • Susana Guerra
Francisco Sánchez-Madrid
Centro Nacional de Investigaciones Cardiovasculares Carlos III

Corresponding Author:[email protected]

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Irene Fernández-Delgado
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Raquel Castillo-González
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Raúl Izquierdo-Serrano
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Elena Moya-Ruiz
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Marta Ramírez-Huesca
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Olga Moreno-Gonzalo
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Ana Rodríguez-Galán
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Nieves Fernández-Gallego Anaya
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Alberto Fernández-Bernaldez
Universidad Autonoma de Madrid
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Javier Sanchez-Perez
Universidad Autonoma de Madrid
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Danay Cibrian
Centro Nacional de Investigaciones Cardiovasculares Carlos III
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Hortensia de la Fuente
Universidad Autonoma de Madrid
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Susana Guerra
Universidad Autonoma de Madrid Departamento de Medicina Preventiva y Salud Publica y Microbiologia
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Abstract

The role of ISG15 (Interferon-Stimulated Gene 15) is becoming increasingly acknowledged in cancer, pathogen infection and inflammatory immune diseases. ISG15 expression increases in human psoriatic skin, and genetic mutations of ISG15 cause dermatological alterations. Here, we show that ISG15 deficiency leads to reduced inflammation and swelling in a murine model of allergic contact dermatitis (ACD). Bone marrow transplantation and adoptive transfer approaches demonstrate that ISG15 alters dendritic cell (DC) responses in the ACD mouse model. Consistently, Isg15-deficient DCs secrete reduced amounts of pro-inflammatory cytokines, including IL-1β and IL-12. This study opens new avenues to potentiate immunotherapies to treat immune-related dermatological disorders.