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FOOD ALLERGEN SENSITIVITY AND THE PROGNOSIS OF WHEEZING IN CHILDREN
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  • Ozge Yilmaz,
  • Cecilia Patino,
  • Fatma Taneli,
  • Esra Toprak kanık,
  • Ahmet Turkeli,
  • Ceyhun Gozukara,
  • Sezen Irmak,
  • Hasan Yüksel
Ozge Yilmaz
Celal Bayar Universitesi Tip Fakultesi

Corresponding Author:[email protected]

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Cecilia Patino
University of Southern California Keck School of Medicine
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Fatma Taneli
Celal Bayar Universitesi Tip Fakultesi
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Esra Toprak kanık
Celal Bayar Universitesi Tip Fakultesi
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Ahmet Turkeli
Celal Bayar Universitesi Tip Fakultesi
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Ceyhun Gozukara
Celal Bayar Universitesi Tip Fakultesi
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Sezen Irmak
Celal Bayar Universitesi Tip Fakultesi
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Hasan Yüksel
Celal Bayar Universitesi Tip Fakultesi
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Abstract

Background : We aimed to investigate food allergen sensitization as a prognostic factor of new onset wheezing episodes as well as of wheezing severity during follow up in young children with recurrent wheezing. Our secondary aim was to compare serum levels of Club Cell-16 (CC-16) and surfactant protein D (SP-D) among wheezing children with and without food allergen sensitization as potential pathogenetic indicators of the association between food allergen sensitivity and wheezing. Methods : This was a prospective cohort study among children with recurrent wheezing; specific-IgE to five common foods allergens was assessed at baseline and children were followed-up for one year for new onset wheezing episodes. Baseline wheezing severity score, CC-16 and SP-D levels were measured. Results : We enrolled 295 children among which 44 were food specific IgE (Fx5) (+). Poisson regression analysis with food allergen sensitivity, age and wheezing score at presentation revealed that Fx5 positivity changed yearly frequency of wheeze by a factor of 1.66 (p=0.05, 95%CI: (0.99-2.75)). Age changed the yearly frequency of wheeze by a factor of 0.95 (p=0.005, 95%CI: (0.92-0.99)). One-point change in wheezing score at presentation changed the wheezing frequency in the following year by a factor of 1.11 (p=0.005, 95%CI: (0.67-1.99)). Levels of CC-16 and SP-D were not significantly different between the two groups (p=0.679 and p=0.988). Conclusion : Food allergen sensitization defined as serum specific IgE positivity irrespective of food associated clinical allergy findings is associated with worse prognosis of wheezing in children.