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Fatal canine parvovirus type 2a and 2c infections in wild Chinese pangolins ( Manis pentadactyla ) in southern China
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  • 彦 华,
  • Zhang Lina,
  • Wang Kai,
  • An Fuyu,
  • Zhang Dongliang,
  • Hailing Zhang,
  • Xu Xuelin,
  • Guo Ce,
  • Yan Hongmei,
  • Kuang Yingjie,
  • Zhang Zhidong,
  • Lu Rongguang
彦 华
Guangdong Academy of Forestry

Corresponding Author:[email protected]

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Zhang Lina
Guangdong Engineering Polytechic
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Wang Kai
Guangdong Academy of Forestry
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An Fuyu
Guangdong Academy of Forestry
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Zhang Dongliang
Chinese Academy of Agricultural Sciences Institute of Special Animal and Plant Sciences
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Hailing Zhang
Chinese Academy of Agricultural Sciences Institute of Special Animal and Plant Sciences
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Xu Xuelin
Guangdong Academy of Forestry
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Guo Ce
Guangdong Academy of Forestry
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Yan Hongmei
Guangdong Academy of Forestry
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Kuang Yingjie
Guangdong Academy of Forestry
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Zhang Zhidong
Guangdong Academy of Forestry
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Lu Rongguang
School of Medicine Chinese University of Hongkong Shenzhen No2001 Longxiang Avenue Shenzhen 518172 Guangdong Province China
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Abstract

The Chinese pangolin ( Manis pentadactyla) is a critically endangered scale-covered mammal belonging to the order Pholidota. Wild pangolins are notably susceptible to pathogen infection and are typically characterized by impoverished health. However, little is currently known regarding the viruses prevalent among pangolins. In this study, we report the detection of two subtypes of canine parvovirus type 2 (CPV-2), namely, CPV-2a and CPV-2c, both of which caused severe diarrheal disease in two post-rescue pangolins with fatal consequences. As in CPV-2-infected dogs, intensive lesion of the mucosal layer of the small intestines is a prominent feature in infected pangolins. Phylogenetic analysis revealed that the VP2 viral protein sequences isolated from one pangolin were classified into the CPV-2c subclade, with 99.8% identities to a CPV-2c strain (MN832850) isolated from a Taiwanese pangolin found in Taiwan Province. In contrast, VP2 sequences obtained from the second pangolin were classified into the CPV-2a subclade, with 99.8% identities to a CPV-2a strain (KY386858) isolated from southern China. In this study, we thus confirmed the infection of pangolins with CPV-2c in mainland China and demonstrate that CPV-2a can also infect pangolins. Based on these findings, we recommend that further investigations should be conducted to establish the interspecies transmission of these viruses among wild pangolins, wild carnivores, and stray dogs.
31 May 2022Submitted to Transboundary and Emerging Diseases
06 Jun 2022Assigned to Editor
06 Jun 2022Submission Checks Completed
07 Jun 2022Reviewer(s) Assigned
30 Jun 2022Review(s) Completed, Editorial Evaluation Pending
01 Jul 2022Editorial Decision: Revise Major
19 Aug 2022Review(s) Completed, Editorial Evaluation Pending
20 Aug 2022Editorial Decision: Revise Minor
30 Aug 20222nd Revision Received
30 Aug 2022Submission Checks Completed
30 Aug 2022Assigned to Editor
30 Aug 2022Reviewer(s) Assigned
31 Aug 2022Review(s) Completed, Editorial Evaluation Pending
31 Aug 2022Editorial Decision: Revise Minor
01 Sep 20223rd Revision Received
02 Sep 2022Assigned to Editor
02 Sep 2022Submission Checks Completed
03 Sep 2022Review(s) Completed, Editorial Evaluation Pending
03 Sep 2022Editorial Decision: Accept