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Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
  • Nicholas White,
  • James Watson,
  • Kevin Baird
Nicholas White
Faculty of Tropical Medicine, Mahidol Iniversity
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James Watson
Mahidol University Faculty of Tropical Medicine
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Kevin Baird
Eijkman Institute for Molecular Biology
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Abstract

Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moeity of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to therapeutic efficacy against latent vivax and ovale malarias. Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.

Peer review status:Published

22 Nov 2021Submitted to British Journal of Clinical Pharmacology
24 Nov 2021Submission Checks Completed
24 Nov 2021Assigned to Editor
14 Dec 2021Reviewer(s) Assigned
17 Dec 2021Review(s) Completed, Editorial Evaluation Pending
17 Dec 2021Editorial Decision: Revise Minor
18 Dec 20211st Revision Received
20 Dec 2021Submission Checks Completed
20 Dec 2021Assigned to Editor
20 Dec 2021Review(s) Completed, Editorial Evaluation Pending
31 Dec 2021Editorial Decision: Accept
07 Jan 2022Published in British Journal of Clinical Pharmacology. 10.1111/bcp.15219