A comprehensive examination of ACE-2 receptor and prediction of spike
glycoprotein and ACE-2 interaction based on in silico analysis of ACE-2
receptor
Abstract
ACE-2 receptor plays a vital role not only in the SARS-CoV-induced
epidemic but also in some diseases. Studies have been carried out on the
interactions of ACE-2- SARS-CoV proteins. However, comprehensive
research has not been conducted on ACE2 protein by using bioinformatic
tools. The present study especially two places, G104 and L108 points,
which are effective in protecting the structure of the ACE-2 protein,
play a critical role in the biological functioning of this protein, and
play an essential role in determining the chemical-physical properties
of this protein, and play a crucial role for ACE-2 protein-SARS CoV
surface glycoprotein, were determined. It was also found that the G104
and L108 regions were more prone to possible mutations or deletions than
the other ACE-2 protein regions. Moreover, it was determined that all
possible mutations or deletions in these regions affect the
chemical-physical properties, biological functions, and structure of the
ACE-2 protein. Having a negative GRAVY value, one transmembrane helix, a
significant molecular weight, a long-estimated half-life as well as most
having unstable are results of G104 and L108 points mutations or
deletions. Finally, it was determined that LQQNGSSVLS, which belong to
the ACE-2 protein, may play an active role in binding the spike protein
of SARS-CoV. All possible docking score results were estimated. It is
thought that this study will bring a different perspective to ACE-2
_SARS-CoV interaction and other diseases in which ACE-2 plays an
important role and will also be an essential resource for studies on
ACE-2 protein.