Most countries around the world including the United States took actions to control COVID-19 spread that lead to an abrupt shift in human activity. On-road NOx emissions from light and heavy-duty vehicles decreased by 9% to 19% between February and March at the onset of the lockdown period in the middle of March in most of the US; between March and April, the on-road NOx emissions dropped further by 8% to 31% when lockdown measures were the most stringent. These precipitous drops in NOx emissions correlated well with tropospheric NO2 column amount observed by the Sentinel 5 Precursor TROPOspheric Monitoring Instrument (S5P TROPOMI). Furthermore, the changes in TROPOMI tropospheric NO2 across the continental U.S. between 2020 and 2019 correlated well with changes in on-road NOx emissions (r = 0.68) but correlated weakly with changes in emissions from the power plants (r = 0.35). At the height of lock-down related unemployment in the second quarter of 2020, the NO2 values decreased at the rate of 0.8 µmoles/m2 per unit percentage increase in the unemployment rate. Despite the lifting of lockdown measures, parts of the US continued to have ~20% below normal on-road NOx emissions. To achieve this new normal urban air quality in the US, continuing remote work policies that do not impede economic growth may become one of the many options.